Huperzine A: The Brain & 11 Powerful Researched Benefits |
By Category X

Huperzine A: The Brain & 11 Powerful Researched Benefits



Huperzine A is an alkaloid. It’s found in a particular species of Lycopodium, or clubmoss, one of the oldest and most prehistoric plant type groups in the world.

It was the clubmoss itself that was originally used for healing and as medicine in ancient times.

Yet with the rise of modern science and studies, it was found that huperzine A was truly responsible for this plant’s effects.

What research found most remarkable about huperzine A: it behaved much like a neurotransmitter. This means it affects nervous system receptors in the brain, while also altering levels of neurotransmitters circulating in the body.


The strange plant in question from which huperzine A originates: a clubmoss called Japanese, Chinese, or toothed clubmoss.

Its scientific name: Huperzia Serrata, where the compound gets its name.

This plant was used in traditional healing practices like Traditional Chinese Medicine (TCM), an herbal folk practice still widely in use today.

Back then, this clubmoss was used for many ailments, for which science has uncovered fascinating revelations about.


If there was ever a powerful medicine for the brain and nerves, toothed clubmoss was it—at least in ancient times in the Eastern part of the world.

In China and Japan particularly, clubmosses were utilized for many issues, most notably for the brain.

Depression, memory problems, and more were all a part of its virtues. It was also considered a good liver and spleen medicine.

Toothed clubmoss should not be confused with other types of clubmoss used in herbalism of the Western world, which fall under the genus Lycopodium. Research shows that these plants do not contain huperzine A at all.


History and general info aside, what can this ancient species of clubmoss do?

More specifically: what is huperzine A, its active constituent, truly capable of?

Civilizations and cultures of old, through their own careful study and evidence-based use, found many amazing health purposes for this plant and its compounds. Today, science supports these discoveries—and is discovering more and more about them each year.

The following are the most research-supported benefits of huperzine A so far discovered, honoring its traditional uses, too.


What really made an unsuspecting clubmoss work as an herbal medicine for the mind?

It’s probably because huperzine A is a potent neuroprotector.

Generally speaking, all its benefits for the brain and nerves owe to this fact. Ancient healers knew this, though recent studies have discovered this property, too.

One study in 2011 gave a detailed analysis of huperzine A’s potential, deeming it ripe for future exploration in developing neuroprotective drugs.

In another study, huperzine A’s effects showed actual “neurogenesis” in certain parts of the brain, meaning that it stimulated both nerve and brain tissue growth on top of protecting it.


Since neurological disorders—like Parkinson’s, ADHD, and autism—develop depending on the health and state of the nervous system and brain tissues, many scientists and researchers have presupposed that huperzine A could support or reduce their risk as a neuroprotector.

Not to add that in ancient times, before there were names for these diseases, clubmoss was a frontline remedy for such issues.

As a result, huperzine A has drawn great attention for neurological conditions. More specifically, studies show that huperzine A is an AChE (acetylcholinesterase) inhibitor, meaning it can block pathways leading to neurological disorders—specifically dementia and Alzheimer’s.


There are possibilities in huperzine A to help all sorts of neurological disorders, though none have been more studied—or seem as likely and promising—as the alkaloid’s studied effects on Alzheimer’s disease.

More than any other neurological disorder, AChE inhibitors like huperzine A have the most powerful effects on Alzheimer’s.

This neurodegenerative disease is characterized by a slow loss of memory, cognitive dysfunction, and advanced dementia. And yet, studies show this clubmoss compound could reduce the risk of Alzheimer’s and improve its symptoms.

More studies will be needed, but this has opened up some very hopeful avenues for considering huperzine A a possible Alzheimer’s drug one day.


Even if Alzheimer’s is not in the picture, there are the occasions that symptoms like cognition and focus problems can affect peoples’ lives with or without the condition.

Rest assured that, same as Alzheimer’s, huperzine A could help just about anybody in the brain health department.

Having trouble with slow thinking, multi-tasking, or even memory issues? Studies show that, on the one hand, huperzine A improved visual memory and recognition in certain test subjects.

In another study, the plant alkaloid boosted cognitive function in subjects who were struggling in that department.


In addition to more common struggles with cognition and memory, studies also suggest huperzine A could help issues like brain fog or mental fatigue, a sub-clinical problem that can give rise to both poor memory and cognition while posing its own unique challenges.

One study in fact connected the folk herbalism use of clubmoss for chronic fatigue issues to its huperzine A content.

What’s more, brain fog isn’t an issue that just happens on its own. It can be a frustrating consequence of other health struggles like autoimmune disorders, digestive dysfunction, certain nervous conditions, or adrenal fatigue.


The plant-based alkaloid’s benefits for memory, fatigue, and Alzheimer’s can seem intangible. After all, these are aspects of mental or nervous health it helps with that are hard to measure.

Yet there’s more than meets the eye with huperzine A, especially when taking its effects on nervous pain into consideration.

One study showed that use of huperzine A could one day be a candidate for developing holistic and long-term nerve pain management medications. The reason: it visibly alleviated pain in test subjects that experienced nerve injury.

This could bring hope for those with chronic nerve pain, fibromyalgia, and more.


Returning to huperzine A as an AChE inhibitor, research shows an encouraging outlook for those with epilepsy.

In a 2015 study, use of huperzine A reduced the incidence of seizures in test subjects with epilepsy.

Much like its study results with Alzheimer’s, the botanical compound inhibited and affected certain pathways related to the occurrence of seizures, particularly GABA-related pathways. What’s more, it didn’t need the help of other anti-epileptic treatments to work effectively.

Natural alternatives for treating epilepsy are few. Fortunately, with this research, there could possibly be some right around the corner thanks to huperzine A.


In the same realm as seizures and epilepsy, huperzine A could help other major disorders that have life-changing and hampering effects—namely, it can help brain damage.

This extends to complications and damage due to concussions, stroke, or other trauma.

A study in 2015 addressed this by way of testing huperzine A’s impacts on brain damage. In the study, the alkaloid protected the brain from any further damage or injury owing to a hemorrhage.

Could this possibly make it a medicine for stroke or concussions? Not yet, but it certainly does open a door up to the possibility.


For some, anxiety or depression seems like nothing but an emotional issue. For millions of others, however, this is not the case.

Anxiety and depression are very much neurological issues, for which huperzine A could show benefit for.

One study on huperzine A showed that it had specific biochemical interactions for anxiety, doing so by blocking receptors that heightened anxiety and altering neurotransmitters that caused it, too.

As for depression, a 2017 study revealed that the plant chemical could behave very much like a natural anti-depressant, though how effective it is compared to pharmaceutical anti-depressants is still uncertain.


It’s important to note that clubmoss, the source of huperzine A and its traditional uses, wasn’t just used for improving the nervous system, mental health, and neurological function.

In fact, according to Traditional Chinese Medicine both today and in the past, toothed clubmoss was also a liver medicine.

What’s more, these liver health-boosting properties are also owed to huperzine A. A study in 2013 showed that its AChE inhibiting benefits apparently reduce inflammation in the liver, thereby enhancing its health and function.

For a lot of people, this could make it a great supplement for natural detoxification support.


Many herbs and supplements claim to help with substance addiction, but few of them have the research and science to prove this.

Not the case with huperzine A, which shows promising research and benefits for addiction.

Though a very preliminary study that requires further investigation, one piece of research showed huperzine A may slow or alter the way one immediately responds to addiction, showing hope for further development and exploration in the alkaloid for addiction treatment and management.

It’s untested for now, but huperzine A may provide holistic support for those undergoing (or trying to quit) addictions to tobacco, alcohol, or even hard drugs, though more studies will ultimately be needed.

Huperzine A is one of many botanical ingredients we love—and one of many also backed by science and tradition to be a powerful booster to the brain, nervous system, overall neurological health, and more.

We’ve included each of these in our neuro-boosting formula, Neuro Shroom.

Our huperzine A is all-natural, extracted from whole herb club moss from the Huperzia Serrata plant.

Plus, our formula also contains:


Maung Kyaw Moe Tun, Daniel-Joachim Wustmann, Seth B. Herzon (2011). A robust and scalable synthesis of the potent neuroprotective agent (-)-huperzine A. Chemical Science 2:2251-2253. Retrieved from
Tuo Ma, Kai Gong, Yufang Yan, Lihai Zhang, Peifu Tang, Xiufang Zhang, Yadao Gong (2013). Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. Brain Research Vol. 1506 pp. 35-43. Retrieved from
Sibhghatulla Shaikh, Anupriya Verma, Saimeen Siddiqui, Syed S. Ahmad, Syed Rizvi, Shazi Shakil, Deboshree Biswas, Divya Singh, Mohmmad H. Siddiqui, Shahnawaz Shakil, Shams Tabrez, Mohammad A. Kamal (2014). Current Acetylcholinesterase-Inhibitors: A Neuroinformatics Perspective. CNS & Neurological Disorders – Drug Targets 13(3) 391-401(11). Retrieved from
Guoyan Yang, Yuyi Wang, Jinzhou Tian, Jian-Ping Liu (2013). Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. PLoS ONE 8(9) e74916. Retrieved from
Ludise Malkova, Alan P. Kozikowsi, Karen Gale (2011). The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology 60(7-8) 1262-1268. Retrieved from
Xiao-Yuan Mao, Dan-Feng Cao, Xi Li, Ji-Ye Yin, Zhi-Bin Wang, Ying Zhang, Chen-Xue Mao, Hong-Hao Zhou, Zhao-Qian Liu (2014). Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats. International Journal of Molecular Science 15(5) 7667-7683. Retrieved from
Jhilik Banerjee, Sunipa Biswas, Nithar Ranjan Madhu, Susanta Roy Karmakar, Surjyo Jyoti Biswas (2014). A better understanding of pharmacological activities and uses of phytochemicals of Lycopodium clavatum: A review. Journal of Pharmacognosy and Phytochemistry 3(1) 207-210. Retrieved from
Dou Yu, Devang K. Thakor, Inbo Han, Alexander E. Ropper, Hariprakash Haragopal, Richard L. Sidman, Ross Zafonte, Steven C. Schachter, Yang D. Teng (2013). Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A. Proceedings of the National Academy of Sciences of the United States of America 110(8). Retrieved from
  1. Gersner, D. Ekstein, S.C. Dhamne, S.C. Schachter, A. Rotenberg (2015). Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. Epilepsy Research Vol. 117 pp. 97-103. Retrieved from
Haiying Lu, Mei Jiang, Lei Lu, Guo Zheng, Qiang Dong (2015). Ultrastructural mitochondria changes in perihematomal brain and neuroprotective effects of Huperzine A after acute intracerebral hemorrhage. Neuropsychiatric Disease and Treatment 11:2649-2657. Retrieved from
Jaswinder Kaur, Rajmeet Singh, Parminder Singh, Jasvir Kaur, Harpreet Kaur (2017). Anxiolytic and Motor Coordination Activity of Huperzine-A in Rats. International Journal of Pharmaceutical Sciences and Research 8(6) 2560-2566.
Yuan Du, Haiyue Liang, Leiming Zhang, Fenghua Fu (2017). Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression. Pharmacology Biochemistry and Behavior Vol. 158 pp. 32-38. Retrieved from
Qingwei Ruan, Fang Liu, Zhanjuan Gao, Deqiu Kong, Xiaona Hu, Dongmei Shi, Zhijun Bao, Zhuowei Yu (2013). The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats. Mechanisms of Ageing and Development 134(3-4) 89-97. Retrieved from
Jingling Sun, Lin Tian, Ruisi Cui, Xinwang Li (2017). Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats. Experimental and Therapeutic Medicine 13(4) 1584-1591. Retrieved from


AMPK | The Enzyme That Powers on Energy, Metabolism and Autophagy

If only there was a way to measure energy in the body—or a way to know how to naturally tap into its health-enhancing abundance. In a search for such insights, science and research have led …

By Primal Herb

Can You Help Protect the Brain from a Stroke Naturally?

We face temptations and hazards to our physical health almost every day. Some of these we think and talk about often, such as heart disease and high blood pressure. But do we think enough about what …

By Primal Herb

Glucose Meter: Great Tool to Optimize Health & Longevity

Ever wonder if unhealthiness is something that can be felt—or even measured? Some of us may already know the answer to this question. After eating certain foods, something may just not feel quite right. Maybe …

By Primal Herb