Chaga Mushroom

Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus)
extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

Extract of Chaga mushroom (Inonotus obliquus) stimulates 3T3-L1 adipocyte differentiation

Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom,
Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae)

Chaga mushroom-induced oxalate nephropathy

Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus
(higher Basidiomycetes), on the proliferation of human neurogliocytoma cells

A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in
the Vero cells infected with the herpes simplex virus

Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”

Antiinflammatory and Immunomodulating Properties of Fungal Metabolites

Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells

Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses
cancer progression and maintains body temperature in mice

Elderberry Extract

Elderberry for prevention and treatment of viral respiratory illnesses – This study suggests that Elderberry may be a safe option for treating viral respiratory illnesses without evidence of overstimulating the immune system.

Anti-influenza virus effects of elderberry juice and its fractions – Evaluates the antiviral effect of concentrated elderberry juice against influenza.

The effect of Sambucol, a black elderberry-based, natural product, on the duration of flu symptoms – Sambucol was shown to be effective in vitro against 10 strains of influenza virus and reduced the duration of flu symptoms.

Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections – Elderberry extract seems to offer an efficient, safe, and cost-effective treatment for influenza.

Polysaccharides from European Black Elderberry Extract Enhance Innate Immune Responses – Discusses how European black elderberry may treat common colds or influenza infections through immune response enhancement.

The Pros and Cons of Using Elderberry (Sambucus nigra) for the Prevention and Treatment of Viral Diseases – Reviews current evidence on the appropriateness of elderberry for the prevention and initial treatment of viral diseases.

Rational and Safe Use of the Top Two Botanical Dietary Supplements in the United States – Discusses elderberry and Echinacea extracts’ influence on the immune system.

HIV type-1 entry inhibitors with a new mode of action – Elderberry, green tea, and cinnamon extracts were shown to block HIV-1 entry and infection.

Trace Minerals, Vitamins and Nutraceuticals in Prevention and Treatment of Viral Infections – Although not exclusively on elderberry, this study includes it in the context of immune system support against viral infections.

Immune-enhancing role of vitamin C and zinc and effect on clinical conditions – This study discusses the role of vitamin C and zinc in the immune system, which can be relevant when considering elderberry’s effects as part of a holistic approach to immunity.

Turkey Tail Mushroom

Discovery of novel xylosides in co-culture of basidiomycetes Trametes versicolor
and Ganoderma applanatum by integrated metabolomics and bioinformatics

Potential activities and mechanisms of extracellular polysaccharopeptides from fermented
Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer

Trametes versicolor Mushroom Immune Therapy in Breast Cancer

Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected
Trametes species from Serbia

Tramesan, a novel polysaccharide from Trametes versicolor

Trametes versicolor Protein YZP Activates Regulatory B Lymphocytes – Gene Identification
through De Novo Assembly and Function Analysis in a Murine Acute Colitis Model

Olive Leaf

Antiviral activity of polyphenols found in olive leaf – This research delves into the antiviral properties of olive leaf polyphenols against viruses such as HPV and HCV, showcasing olive leaf extract’s potential in enhancing viral defense mechanisms. Read more on NCBI.

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds – Highlights the significant antiviral, anti-inflammatory, and immunomodulatory properties of compounds derived from olive tree by-products. Read more on NCBI.

Strong antiviral impact of olive leaf extract against various viruses – Confirms the potent antiviral effects of olive leaf extract and its positive influence on the clinical status of patients with viral infections. Read more on ScienceDirect.

Olive Leaves as a Potential Phytotherapy in the Treatment of Viral Infections – Reviews the comprehensive benefits of olive leaf extract, including its antiviral, anti-inflammatory, immunomodulatory, and antioxidant properties. Read more on Frontiers in Pharmacology.

Analysis of Antioxidant and Antiviral Effects of Olive (Olea europaea L.) Leaf Extracts – Assesses the antioxidant and antiviral effectiveness of olive leaf extracts, emphasizing their role in immune support and natural defense against viruses. Read more on MDPI.

Analysis of Antioxidant and Antiviral Effects of Olive (Olea europaea L.) Leaf Extracts – Assesses the antioxidant and antiviral effectiveness of leaf extracts from Olea europaea L. var. sativa.

The Effect of Olive Leaf Extract on Upper Respiratory Illness in High School Athletes – Investigates Olive Leaf Extract (OLE) containing oleuropein and hydroxytyrosol for their antiviral properties.

Anti-influenza virus activity of the elenolic acid rich olive leaf (Olea europaea L.) – This study tests the anti-influenza activity of a standardized olive leaf extract rich in elenolic acid.

Immune Competence  – Discusses olive leaf extract among other substances for their antiviral and immune-enhancing effects.

Olive Leaf | Memorial Sloan Kettering Cancer Center – This resource from a reputable cancer center mentions olive leaf extract’s potential in increasing the effectiveness of blood pressure medication, indicating its cardiovascular benefits. Read more at MSKCC.

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Constituents – This piece explores olive leaf extract’s (OLE) anti-inflammatory and antioxidant properties through in vitro and in vivo studies. It emphasizes the potential health benefits related to its bioactive components. Read more on NCBI.

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health – This article discusses the various health benefits of oleuropein, a key polyphenol found in olive leaf extract. It highlights anti-inflammatory effects, including the inhibition of lipoxygenase activity and leukotriene B4 production, which contribute to its beneficial properties. Read more on NCBI.


Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity – This study discusses the potential of betulin derivatives in reducing inflammation and inducing cell death in murine macrophages, suggesting its anti-inflammatory properties. Read more on NCBI.

Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents – This research explores the antiviral properties of betulin and its derivatives against various viruses, highlighting its potential as an antiviral agent. Read more on ScienceDirect.

A Review on Preparation of Betulinic Acid and Its Biological Activities – Provides an overview of the biological and pharmacological properties of betulinic acid, including its anti-inflammatory, antibacterial, antiviral, and antidiabetic effects. Read more on NCBI.

Anti-Inflammatory Activities of Betulinic Acid: A Review – This review article covers the anticancer activity of betulinic acid and its cytotoxic effects against various types of cancer cells, indirectly suggesting its immune system modulation capabilities. Read more on Frontiers.

Engineering antiviral immune-like systems for autonomous virus detection and inhibition – Although not directly focused on betulin, this research discusses engineering antiviral immune-like systems for biomedical applications, which could be relevant when considering the role of betulin in immune system modulation. Read more on Nature.

Pharmacological Potential of Betulin as a Multitarget Compound – This review underscores the varied beneficial effects of betulin across different diseases, attributing these benefits to its multifaceted pharmacological actions. The research presents betulin as a promising compound for further investigation due to its diverse therapeutic effects. Read more on NCBI.

A Review on Preparation of Betulinic Acid and Its Biological Activities – This article provides a comprehensive review of betulinic acid’s physiological and pharmacological activities, emphasizing its significant interest in research for its potent activities. Read more on NCBI.

Betulin – An Overview – This piece from ScienceDirect discusses the antimicrobial properties of betulin, citing studies that have tested its efficacy as an antimicrobial agent, particularly noting research efforts from Asia. Read more on ScienceDirect.

Betulin and betulinic acid: triterpenoids derivatives with a powerful anticancer impact – Published in Springer, this article explores the ability of betulin derivatives to induce apoptosis in numerous cancer cell lines, highlighting their potential as anticancer agents. Read more on Springer.


The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb – Discusses the triterpenoids in licorice responsible for its antiviral activity and the possible mechanisms for virus prevention. Read more on NCBI.

Can Antiviral Activity of Licorice Help Fight Infection? – Explores how glycyrrhizin or aqueous licorice extracts inhibit the growth and replication of various viruses, highlighting its antiviral capacity. Read more on NCBI.

Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives – Reveals that glycyrrhizin diammonium has a direct antiviral activity and can completely inhibit cell infection, emphasizing its potent antiviral properties. Read more on Frontiers.

Licorice: A Potential Herb in Overcoming Infections – Indicates that licorice or Glycyrrhizae (GR) possesses antiviral, immunomodulatory, and anti-inflammatory properties, showcasing its potential against infections. Read more on Sage Journals.

The potential of glycyrrhizin and licorice extract in combating infection – Suggests that triterpenoids of licorice, mainly glycyrrhizin, are responsible for the reported antiviral activity. Read more on ScienceDirect.

Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions – Demonstrates that glycyrrhizin and glycyrrhetinic acid in licorice can be used as potential antiviral drugs. Read more on MDPI.

Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents – Finds that glycyrrhizin, the major component of licorice root extracts, could moderately inhibit PEDV infection, showcasing its antiviral and anti-inflammatory capabilities. Read more on ACS Publications.

Glycyrrhizin in licorice root neutralizes viruses in vitro – Concludes that glycyrrhizin effectively neutralizes viruses by inhibiting the viral main protease, highlighting its antiviral efficacy. Read more on News Medical.

A Review of the Antiviral Activities of Glycyrrhizic Acid, Glycyrrhetinic Acid, and Licorice Preparations – Reviews licorice’s therapeutic applications, including its antiviral properties. Read more on MDPI.

Exploring the Immunomodulatory and Anti-Inflammatory Properties of Licorice Extract – Licorice extract is highlighted as a commonly used Chinese herbal medication with key components that offer immunomodulatory benefits. Read more on Hindawi.

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