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Gynostemma Plus: Ampk Activator & Adaptogen Support*

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Product Description

Gynostemma PLUS is formulated from Traditional Chinese Medicine (TMC) principles. In TCM, single herbs are rarely used – as herbal formulations (combinations) that are correctly balanced have more therapeutic effectiveness and achieve the outcome more predictably – Feel the difference of Primal Herb.

Effective, AMPK ACTIVATOR & Adaptogen Support*

Gynostemma PLUS May Help By:

What Customers Are Saying:

Average Score: 5 (5 ratings)
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78 years old, more power now............!

I have no problem taken this product. It has given me the ability to do more garden work. Also helps me to be in the day, not all ways 30 to 40 years in the past. When I wake up that’s it, this is my day……………….!!!!

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Awesome!!

This is an amazing product. I Highly recommend primal herbs. I have been taking gynostemma for a few years and it has helped with long term energy, weight management, better sleep, focus etc. I do wish they would continue making the pure gynostemma extract.

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Great product!

I purchased this product two months ago. So far it’s been working great! More mental clarity and more energy. I see some people say it does not taste good!!! Come on guys! what do you expect a botanical extract with medicinal properties taste? taste like chocolate? It tastes however it naturally tastes based on its molecular profile.. Not tasting good is a very little price you have to pay for a greater health benefit.. Indeed if you ever buy a botanical extract that tastes so good, throw it away because it’s most likely fraudulent.

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I take first thing in the morning ever other day seems very poten, pleasant taste

I have not tried this product before, It seems to work well for me. I only started one week ago. So far so good

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Gynostemma

Good product

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Formulated for Effectiveness

Each Ingredient Must Have Historical Use & Independent Studies!

What exactly goes into our Gynostemma PLUS formula? Each completely natural addition is chosen for its proven effectiveness, safety, research, and historical use.*

Gynostemma or Jiaogulan/Jiao-Gu-Lan (Gynostemma pentaphyllum)
What better than to choose the herb most famous for longevity (and to headline its name in our formula) as the leading star for our age-supporting formula? Gynostemma has an almost mythic reputation as a super-healer descended from high peaks in southern China.

Gynostemma also has way more health benefits than the average herb.

This makes it the ultimate adaptogen tonic, no less for helping all aspects of health (which can obviously add more years to one’s life). It can help do this by healing the body against stress, slashing cancer risk, providing antioxidants, boosting energy, and more, research shows. Supporting Research 1–14

Goji Berry or Wolfberry (Lycium barbarum)
Introducing one of our favorite new herbal (as well as nutritious and delicious edible!) ingredients: the goji berry. 

Goji berry has taken health food stores and markets by storm.

And no wonder. Beyond being absolutely tasty, it has health benefits galore. Scientific studies have established it is capable of the following and much more: strong antioxidant action, inflammation fighting, and cancer risk reduction. Supporting Research 15–23

Tibetan Rhodiola (Rhodiola sacra)
There are many different species of rhodiola, and they are always native to high altitude, high latitude areas of the world. However, we chose to select one of the most unique, singular strains for our longevity formula: the holy Tibetan rhodiola, which grows on the slopes of the Himalayas.

Experience the herbal zen energy of these holy, Buddhism-inspired lands.

Tibetan rhodiola has all the same benefits as other rhodiola species. This includes—as held by traditional Tibetan herbalism, and modern research— powers to help blood sugars, boost antioxidants, heal inflammation, and improve overall quality (and possibly, length) of life. Supporting Research 24–32

Gynostemma Plus also includes piperine, the active alkaloid chemical found in the rinds of black pepper fruits (or corns). This compound immediately increases the bioavailability of all other powerful plant compounds added to this blend – so you can really feel the difference!*

We Only Cultivate & Harvest The Purest Sourced Botanicals

AMPK Activator & Adaptogen Support – No Matter How You Mix It!

OUR PROCESS FROM START TO FINISH:

The Quality of Our Products, Knowledge, and Compassion Allows for The Perfect Experience.

We source Pure Raw Ingredients that are sustainably grown and harvested from around the world. Always making sure they’re free of chemical fertilizers and pesticides.

High-Quality Processing Includes:

  • Pretreatment: Cleaning and separating only this highest quality raw material.
  • Dual Extraction Process: both water and alcohol extraction. This process allows for the extraction of some of the most active and bioavailable compounds. In the extraction process, we use purified water and Non-GMO ethanol.
  • Filtration: Once the extraction process is complete we filter using a multiple pass filtration system, to ensure purity.
  • Concentrate: We then concentrate the extract to needed potency.
  • Drying: We spray dry without any heat to ensure no denigration of potency.
  • Sieving: We then run the dried extract powder through a sieving and meshing process to ensure the proper consistency of the texture.
  • Testing: Once complete the finished product is sent to our Quality Control Center in the US. Then on to fulfillment centers located throughout the US for prompt delivery.

Effective, All Natural – Plus a 1 Year Money Back Guarantee!

IT’S NOT THE YEARS IN A LIFE – IT’S THE LIFE IN THE YEARS

We believe in this mantra profoundly. More than just wanting to live longer, the best, purest longevity benefits also mean breathing more LIFE and VIBRANCY into those very same years: by building up health, ALL health, one block at a time.

This means finding herbs, nutrients, and foods with the most wellness properties.

The best life and longevity isn’t possible through the ordinary. That’s why we’ve carefully hand-picked only the most unique, extraordinary herbs to go into this formula perfect for aging, and all the most common health concerns that go with this necessary rite of passage.

GOJI BERRY (OR WOLFBERRY)

If you haven’t heard of this antioxidant-packed berry yet, you’re missing out. Goji berries are a popular and beloved choice for anyone seeking to boost their overall health, especially with the help of fighting free radicals, though this food-meets-herbal medicine is capable of lots more than that.*

Best of all, this exotic Asian berry can now be found practically anywhere.

But there’s no better place to find it than alongside other longevity-promoting ingredients.

How can goji berry improve aging and quality of life in the meantime? Studies (and traditional texts) suggest that it helps detoxify the body (by protecting the liver), reducing cancer risk (fighting free radicals through antioxidants), neuroprotection, immune-boosting, and the list certainly doesn’t end there.*

GYNOSTEMMA (JIAOGULAN)

This powerful herb was fabled to confer an incredibly long life to those who partook of it. Some claims over the centuries have been tremendous, though its discovery and traditional use have a strong basis for very real longevity possibilities.

For one, cultures living near its native habitat often reached ages older than 100.

This only applied to native cultures in southern China (where the herb is from) that drank a tea of the herb every day.

A cascade of scientific research on this humble plant soon followed, establishing strong evidence that gynostemma indeed may protect health by reducing the effects of stress, fighting free radicals, increasing energy, relieving pain, and possibly even stopping cancer in its tracks (though more studies are needed).*

TIBETAN RHODIOLA (RHODIOLA SACRA)

The high secluded regions of the Himalayan mountains have always held some of the best-guarded secrets to inner peace, healing, bountiful health, and yes, longevity. Tibetan Rhodiola, an offshoot of the very same adaptogen Rhodiola seen in the health supplement sections, just so happens to embody all those things.

With the nickname “Plateau Ginseng,” this herb is not to be underestimated.

Studies on many different strains of Rhodiola show that all of them have similar, overlapping, and very powerful gifts for the health-seeker, especially those desiring the utmost health as they grow older. These include: better mental energy, better physical energy, resilience to stress and depression, increased immunity, gut health, and much more.*

We believe purity and sustainability are also a pivotal part of sourcing ingredients that best prime us for passage into old age.

Only the highest quality ensures the highest potential for optimal longevity. This is why we only (and carefully) select ingredients that are sustainably and responsibly sourced, harvested, or grown in their native regions around the world.

BETTER TOGETHER: FIND ALL OF THESE IN GYNOSTEMMA PLUS

Instead of seeking out each of these longevity-enhancing ingredients on their very own, why not experience their magic all together? Save money on several different supplements, and instead find all of them in one in this pure and sustainably harvested supplement blend.

With Gynostemma PLUS, you’ll taste the difference—and the synergy.

In true honor of Ayurvedic practices, these three ingredients—popular healing herbs of the Ayurveda tradition itself—synergistically enhance and complement each other’s effects better combined than when taken alone.

With Gynostemma, Goji Berry, and Tibetan Rhodiola together in Gynostemma PLUS, you have three powerhouse adaptogen botanicals all in one blend for better energy, vitality, and longevity.* That is a guaranteed boost to health, no matter how you mix it!

Balance Restore Optimize!

1.
Li L, Jiao L, Lau B. Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Cancer Biother. 1993;8(3):263-272. [PubMed]
2.
Huyen V, Phan D, Thang P, Hoa N, Ostenson C. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-357. [PubMed]
3.
Zhang G, Deng J, Wang B, et al. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behav Pharmacol. 2011;22(7):633-644. [PubMed]
4.
Müller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L. Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract. Phytomedicine. 2012;19(5):395-401. [PubMed]
5.
Choi H, Zhao T, Shin K, et al. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules. 2013;18(4):4342-4356. [PubMed]
6.
Shin K, Zhao T, Choi H, Hwang B, Lee C, Lee M. Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson’s disease. Brain Res. 2014;1567:57-65. [PubMed]
7.
Lin-Na S, Yong-Xiu S. Effects of polysaccharides from Gynostemma pentaphyllum (Thunb.), Makino on physical fatigue. Afr J Tradit Complement Altern Med. 2014;11(3):112-117. [PubMed]
8.
Lokman E, Gu H, Wan M, Östenson C. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid Based Complement Alternat Med. 2015;2015:120572. [PubMed]
9.
Zhao T, Shin K, Choi H, Lee M. Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complement Altern Med. 2015;15:323. [PubMed]
10.
Huyen V, Phan D, Thang P, Hoa N, Östenson C. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. [PMC]
11.
Oliynyk S, Oh S. Actoprotective effect of ginseng: improving mental and physical performance. J Ginseng Res. 2013;37(2):144-166. [PMC]
12.
Lin-Na S, Yong-Xiu S. Effects of Polysaccharides from Gynostemma Pentaphyllum (Thunb.), Makino on Physical Fatigue. Afr J Tradit Complement Altern Med. 2014;11(3):112-117. [PMC]
13.
Zhao T, Shin K, Choi H, Lee M. Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complement Altern Med. 2015;15:323. [PMC]
14.
Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016;11:43. [PMC]
15.
Bucheli P, Vidal K, Shen L, et al. Goji berry effects on macular characteristics and plasma antioxidant levels. Optom Vis Sci. 2011;88(2):257-262. [PubMed]
16.
Karioti A, Bergonzi M, Vincieri F, Bilia A. Validated method for the analysis of goji berry, a rich source of zeaxanthin dipalmitate. J Agric Food Chem. 2014;62(52):12529-12535. [PubMed]
17.
Povolo C, Foschini A, Ribaudo G. Optimization of the extraction of bioactive molecules from Lycium barbarum fruits and evaluation of the antioxidant activity: a combined study. Nat Prod Res. April 2018:1-5. [PubMed]
18.
Li S, Liu N, Lin L, Sun E, Li J, Li P. Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration. Int J Ophthalmol. 2018;11(6):970-975. [PMC]
19.
Dursun R, Zengin Y, Gündüz E, et al. The protective effect of goji berry extract in ischemic reperfusion in testis torsion. Int J Clin Exp Med. 2015;8(2):2727-2733. [PMC]
20.
Cheng J, Zhou Z, Sheng H, et al. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther. 2014;9:33-78. [PMC]
21.
de S, Nardi G, de O, Filippin-Monteiro F, Locatelli C. Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome. Oxid Med Cell Longev. 2017;2017:9763210. [PMC]
22.
Nardi G, Farias J, Freire C, et al. Anti-inflammatory Activity of Berry Fruits in Mice Model of Inflammation is Based on Oxidative Stress Modulation. Pharmacognosy Res. 2016;8(Suppl 1):S42-S49. [PMC]
23.
Ma Z, Zhang H, Teh S, et al. Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action. Oxid Med Cell Longev. 2019;2019:2437397. [PMC]
24.
Yoshikawa M, Shimada H, Horikawa S, et al. Bioactive constituents of Chinese natural medicines. IV. Rhodiolae radix. (2).: On the histamine release inhibitors from the underground part of Rhodiola sacra (Prain ex Hamet) S. H. Fu (Crassulaceae): chemical structures of rhodiocyanoside D and sacranosides A and B. Chem Pharm Bull (Tokyo). 1997;45(9):1498-1503. [PubMed]
25.
Yang R, Liu K, Chen X. [Effect of Rhodiola Sacra on left ventricular remodeling and its mechanism in spontaneously hypertensive rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2013;44(2):201-204. [PubMed]
26.
Shih C, Kuo D, Huang C, Gu Y, Chen F. Autonomic nervous system mediates the cardiovascular effects of Rhodiola sacra radix in rats. J Ethnopharmacol. 2008;119(2):284-290. [PubMed]
27.
Ohsugi M, Fan W, Hase K, et al. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999;67(1):111-119. [PubMed]
28.
Fan W, Tezuka Y, Komatsu K, Namba T, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu. Biol Pharm Bull. 1999;22(2):157-161. [PubMed]
29.
Dun Y, Liu S, Zhang W, Xie M, Qiu L. Exercise Combined with <i>Rhodiola sacra</i> Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2017;2017:8024857. [PubMed]
30.
Zhao H, Li Q, Ning G, Han Z, Jiang Z, Duan Y. Rhodiola sacra aqueous extract (RSAE) improves biochemical and sperm characteristics in cryopreserved boar semen. Theriogenology. 2009;71(5):849-857. [PubMed]
31.
Mook-Jung I, Kim H, Fan W, et al. Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biol Pharm Bull. 2002;25(8):1101-1104. [PubMed]
32.
Dun Y, Liu S, Zhang W, Xie M, Qiu L. Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2017;2017:8024857. [PMC]
  1. Li L, Jiao L, Lau B. Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Cancer Biother. 1993;8(3):263-272. [PubMed]
  2. Huyen V, Phan D, Thang P, Hoa N, Ostenson C. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-357. [PubMed]
  3. Zhang G, Deng J, Wang B, et al. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behav Pharmacol. 2011;22(7):633-644. [PubMed]
  4. Müller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L. Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract. Phytomedicine. 2012;19(5):395-401. [PubMed]
  5. Choi H, Zhao T, Shin K, et al. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules. 2013;18(4):4342-4356. [PubMed]
  6. Shin K, Zhao T, Choi H, Hwang B, Lee C, Lee M. Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson’s disease. Brain Res. 2014;1567:57-65. [PubMed]
  7. Lin-Na S, Yong-Xiu S. Effects of polysaccharides from Gynostemma pentaphyllum (Thunb.), Makino on physical fatigue. Afr J Tradit Complement Altern Med. 2014;11(3):112-117. [PubMed]
  8. Lokman E, Gu H, Wan M, Östenson C. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid Based Complement Alternat Med. 2015;2015:120572. [PubMed]
  9. Zhao T, Shin K, Choi H, Lee M. Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complement Altern Med. 2015;15:323. [PubMed]
  10. Huyen V, Phan D, Thang P, Hoa N, Östenson C. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. [PMC]
  11. Oliynyk S, Oh S. Actoprotective effect of ginseng: improving mental and physical performance. J Ginseng Res. 2013;37(2):144-166. [PMC]
  12. Lin-Na S, Yong-Xiu S. Effects of Polysaccharides from Gynostemma Pentaphyllum (Thunb.), Makino on Physical Fatigue. Afr J Tradit Complement Altern Med. 2014;11(3):112-117. [PMC]
  13. Zhao T, Shin K, Choi H, Lee M. Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complement Altern Med. 2015;15:323. [PMC]
  14. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016;11:43. [PMC]
  15. Bucheli P, Vidal K, Shen L, et al. Goji berry effects on macular characteristics and plasma antioxidant levels. Optom Vis Sci. 2011;88(2):257-262. [PubMed]
  16. Karioti A, Bergonzi M, Vincieri F, Bilia A. Validated method for the analysis of goji berry, a rich source of zeaxanthin dipalmitate. J Agric Food Chem. 2014;62(52):12529-12535. [PubMed]
  17. Povolo C, Foschini A, Ribaudo G. Optimization of the extraction of bioactive molecules from Lycium barbarum fruits and evaluation of the antioxidant activity: a combined study. Nat Prod Res. April 2018:1-5. [PubMed]
  18. Li S, Liu N, Lin L, Sun E, Li J, Li P. Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration. Int J Ophthalmol. 2018;11(6):970-975. [PMC]
  19. Dursun R, Zengin Y, Gündüz E, et al. The protective effect of goji berry extract in ischemic reperfusion in testis torsion. Int J Clin Exp Med. 2015;8(2):2727-2733. [PMC]
  20. Cheng J, Zhou Z, Sheng H, et al. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther. 2014;9:33-78. [PMC]
  21. de S, Nardi G, de O, Filippin-Monteiro F, Locatelli C. Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome. Oxid Med Cell Longev. 2017;2017:9763210. [PMC]
  22. Nardi G, Farias J, Freire C, et al. Anti-inflammatory Activity of Berry Fruits in Mice Model of Inflammation is Based on Oxidative Stress Modulation. Pharmacognosy Res. 2016;8(Suppl 1):S42-S49. [PMC]
  23. Ma Z, Zhang H, Teh S, et al. Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action. Oxid Med Cell Longev. 2019;2019:2437397. [PMC]
  24. Yoshikawa M, Shimada H, Horikawa S, et al. Bioactive constituents of Chinese natural medicines. IV. Rhodiolae radix. (2).: On the histamine release inhibitors from the underground part of Rhodiola sacra (Prain ex Hamet) S. H. Fu (Crassulaceae): chemical structures of rhodiocyanoside D and sacranosides A and B. Chem Pharm Bull (Tokyo). 1997;45(9):1498-1503. [PubMed]
  25. Yang R, Liu K, Chen X. [Effect of Rhodiola Sacra on left ventricular remodeling and its mechanism in spontaneously hypertensive rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2013;44(2):201-204. [PubMed]
  26. Shih C, Kuo D, Huang C, Gu Y, Chen F. Autonomic nervous system mediates the cardiovascular effects of Rhodiola sacra radix in rats. J Ethnopharmacol. 2008;119(2):284-290. [PubMed]
  27. Ohsugi M, Fan W, Hase K, et al. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999;67(1):111-119. [PubMed]
  28. Fan W, Tezuka Y, Komatsu K, Namba T, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu. Biol Pharm Bull. 1999;22(2):157-161. [PubMed]
  29. Dun Y, Liu S, Zhang W, Xie M, Qiu L. Exercise Combined with <i>Rhodiola sacra</i> Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2017;2017:8024857. [PubMed]
  30. Zhao H, Li Q, Ning G, Han Z, Jiang Z, Duan Y. Rhodiola sacra aqueous extract (RSAE) improves biochemical and sperm characteristics in cryopreserved boar semen. Theriogenology. 2009;71(5):849-857. [PubMed]
  31. Mook-Jung I, Kim H, Fan W, et al. Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biol Pharm Bull. 2002;25(8):1101-1104. [PubMed]
  32. Dun Y, Liu S, Zhang W, Xie M, Qiu L. Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2017;2017:8024857. [PMC]
Bo Li, Xiaoyu Zhang, Mingzhu Wang, Lili Jiao (2015). Characterization and antioxidant activities of acidic polysacchardies from Gynostemma pentaphyllum (Thunb.) Markino. Carbohydrate Polymers Vol. 127 pp. 209-214. Retrieved from https://www.sciencedirect.com/science/article/pii/S0144861715002829

Hyun Sook Choi, Ting Ting Zhao, Keon Sung Shin, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Lee (2013). Anxiolytic Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum in Mice after Exposure to Chronic Stress. Molecules 18(4) 4342-4356. Retrieved from http://www.mdpi.com/1420-3049/18/4/4342/htm

Zhao T.T., Shin K.S., Choi H.S., Lee M.K. (2015). Ameliorating effects of gypenosides on chronic stress-induced anxiety disorders in mice. BMC Complementary and Alternative Medicine 15(323). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26370834

Wang Jun-Ming, Wang Shuai, Cui Ying (2012). Antidepressant Activities of Extracts from Gynostemma pentaphyllum. Lishizhen Medicine and Materia Medica Research Retrieved from http://en.cnki.com.cn/Article_en/CJFDTotal-SZGY201204014.htm

Dong Jia, Chunguang Rao, Shengxiang Xue, Jinli Lei (2015). Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum. Carbohydrate Polymers 122(20) 93-100. Retrieved from http://www.sciencedirect.com/science/article/pii/S0144861714012284

Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Lee (2010). Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s Disease. Molecules 15(4) 2814-2824. Retrieved from http://www.mdpi.com/1420-3049/15/4/2814

Zhou Wei-Hua, Tan Li-Ming, Mi Chang-Zhong (2012). Effects of gypenosides on the hippocampal cholinergic system in D-galactose induced Alzheimer’s disease in mice. Chinese Journal of Gerontology Retrieved from http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ201222042.htm

  1. Lin-Na, S. Yong-Xiu (2014). Effects of Polysaccharides from Gynostemma Pentaphyllum (Thunb.), Makino on Physical Fatigue. African Journal of Traditional, Complementary and Alternative Medicines 11(3) 112-117. Retrieved from https://www.ajol.info/index.php/ajtcam/article/view/105131/95174

Sun-A Im, Hyun Sook Choi, Soon Ok Choi, Ki-Hyang Kim, Seungjeong Lee, Bang Yeon Hwang, Myung Koo Lee, Chong Kil Lee (2012). Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum components. Molecules 17(7) 7695-7708. Retrieved from http://www.mdpi.com/1420-3049/17/7/7695

Hong-Kan Zhang, Yuan Ye, Zhen-Ni Zhao, Kai-Jun Li, Yi Du, Qiu-Ming Hu, Jian-Feng He (2017) Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis. International Journal of Ophthalmology 10(4) 541-549. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406630/

Hildebert Wagner, Rudolf Bauer, Dieter Melchart, Pei-Gen Xiao, Anton Staudinger (2014). Herba Gynostemmatis – Jiaogulan. Chromatographic Fingerprint Analysis of Herbal Medicines Volume III 55-67. Retrieved from https://link.springer.com/chapter/10.1007%2F978-3-319-06047-7_6

Xiao-Shu Zhang, Jia-Qing Cao, Chen Zhao, Xu-de Wang, Xiao-jun Wu, Yu-Qing Zhao (2015). Novel dammarane-type triterpenes isolated from hydrolysate of total Gynostemma pentaphyllum saponins. Bioorganic & Medicinal Chemistry Letters 25(16) 3095-3099. Retrieved from https://www.sciencedirect.com/science/article/pii/S0960894X15006150

Fei Yang, Haiming Shi, Xiaowei Zhang, Liangli (Lucy) Yu (2013). Two Novel Anti-Inflammatory 21-Nordammarane Saponins from Tetraploid Jiaogulan (Gynostemma pentaphyllum). Journal of Agricultural and Food Chemistry 61(51) 12646-12652. Retrieved from https://pubs.acs.org/doi/abs/10.1021/jf404726z

Wen-Chung Huang, Ming-Ling Kuo, Ming-Liang Li, Rong-Chi Yang, Chian-Jiun Liou, Jiann-Jong Shen (2008). Gynostemma pentaphyllum Decreases Allergic Reactions in a Murine Asthmatic Model. The American Journal of Chinese Medicine 36(3) 579-592. Retrieved from https://www.worldscientific.com/doi/abs/10.1142/S0192415X08005990

Liang Xiao-Hui, Li Wei-Jian, Chen Wen-Pu, Yang Li-Li, Chen Zhi-Ming, Chen Li-Xin, Weng Wen, Zhu Lin-Yan (2012). Anti-hypertensive Effect of Gypenosides in High-glucose-and-Fat-induced Hypertension in Rats. Lishizhen Medicine and Materia Medica Research Retrieved from http://en.cnki.com.cn/Article_en/CJFDTOTAL-SZGY201210016.htm

  1. Müller, A. Gardemann, G. Keilhoff, D. Peter, I. Wiswedel, L. Schild (2012). Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllumextract. Phytomedicine 19(5) 395-401. Retrieved from https://www.sciencedirect.com/science/article/pii/S0944711311005800

V.T.T. Huyen, D.V. Phan, P. Thang, N.K. Hoa, C.G. Östenson (2013). Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. Journal of Nutirtion and Metabolism Vol. 2013 ID 765383. Retrieved from https://www.hindawi.com/journals/jnme/2013/765383/

V.T.T. Huyen, D.V. Phan, P. Thang, P.T. Ky, N.K. Hoa, C.G. Östenson (2012). Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients. Evidence-Based Complementary and Alternative Medicine Vol. 2012 ID 452313. Retrieved from https://www.hindawi.com/journals/ecam/2012/452313/abs/

Soo-Hyun Park, Tae-Lin Huh, Sun-Young Kim, Mi-Ra Oh, P.B. Tirupathi Pichiah, Soo-Wan Chae, Youn-Soo Cha (2013). Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double-blind, placebo-controlled trial. Obesity 22(1) 63-71. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.20539

Jun Liu, Lihua Zhang, Yingang Ren, Yanli Gao, Li Kang, Qing Qiao (2014). Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice. International Journal of Biological Macromolecules Vol. 69 pp. 1-4. Retrieved from https://www.sciencedirect.com/science/article/pii/S0141813014002980

Ko-Chung Tsui, Tzu-Hsuan Chiang, Jinn-Shyan Wang, Li-Ju Lin, Wei-Chih Chao, Bing-Huei Chen, Jyh-Feng Lu (2014). Flavonoids from Gynostemma pentaphyllum Exhibit Differential Induction of Cell Cycle Arrest in H460 and A549 Cancer Cells. Molecules 19(11) 17663-17681. Retrieved from http://www.mdpi.com/1420-3049/19/11/17663

Andrei Mocan, Laurian Vlase, Dan Cristian Vodnar, Cristina Bischin, Daniela Hanganu, Ana-Maria Gheldiu, Radu Oprean, Radu Silaghi-Dumitrescu, Gianina Crisan (2014). Polyphenolic Content, Antioxidant and Antimicrobial Activities of Lycium barbarum L. and Lycium chinense Mill. Leaves. Molecules 19(7) 10056-10073. Retrieved from https://www.mdpi.com/1420-3049/19/7/10056/html

Wen-Bin Wu, Dian-Kun Hung, Fung-Wei Chang, Eng-Thaim Ong, Bing-Huei Chen (2012). Anti-inflammatory and anti-angiogenic effects of flavonoids isolated from Lycium barbarum Linnaeus on human umbilical vein endothelial cells. Food & Function 3, Issue 10, 1068-108. Retrieved from https://pubs.rsc.org/en/content/articlelanding/2012/fo/c2fo30051f/unauth#!divAbstract

Wai-Man Tang, Enoch Chan, Ching-Yee Kwok, Yee-Ki Lee, Jian-Hong Wu, Chun-Wai Wan, Robbie Yat-Kan Chan, Peter Hoi-Fu Yu, Shun-Wan Chan (2012). A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology 20(6) 307-314. Retrieved from https://link.springer.com/article/10.1007/s10787-011-0107-3

Jia Xiao, Emily C. Liong, Yick Pang Ching, Raymond Chuen Chung Chiang, Kwok Fai So, Man Lung Fung, George L. Tipoe (2012). Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. Journal of Ethnopharmacology 139(2) 462-470. Retrieved from https://www.sciencedirect.com/science/article/pii/S0378874111008415

Jing Zhu, Wei Liu, Juping Yu, Shan Zou, Jiajia Wang, Wenbing Yao, Xiangdong Gao (2013). Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. Carbohydrate Polymers 98(1) 8-16. Retrieved from https://www.sciencedirect.com/science/article/pii/S0144861713004128

Meihua He, Hong Pan, Raymond Chuen-Chung Chang, Kwok-Fai So, Nicholas C. Brecha, Mingliang Pu (2014). Activation of the Nrf2/HO-1 Antioxidant Pathway Contributes to the Protective Effects of Lycium Barbarum Polysaccharides in the Rodent Retina after Ischemia-Reperfusion-Induced Damage. PLoS 9(1): e84800. Retrieved from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084800

Chiu-Hsieh (Paul) Hsu, Dwight M. Nance, Harunobu Amagase (2012). A Meta-Analysis of Clinical Improvements of General Well-Being by a Standardized Lycium barbarum. Journal of Medicinal Food 15(11). Retrieved from https://www.liebertpub.com/doi/abs/10.1089/jmf.2012.0013

Qian Zhou, Zhi-Ping Yin, Lei Ma, Wen Zhao, Hong-Wei Hao, Hui-Ling Li (2014). Free radical-scavenging activities of oligomeric proanthocyanidin from Rhodiola rosea L. and its antioxidant effects in vivo. Natural Product Research 28(24) 2301-2303. Retrieved from https://www.tandfonline.com/doi/abs/10.1080/14786419.2014.921786

  1. Andrew Shanely, David C. Nieman, Kevin A. Zwetsloot, Amy M. Knab, Hidetaka Imagita, Beibei Luo, Barbara Davis, Jose M. Zubeldia (2014). Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain, Behavior, and Immunity Vol. 39 pp. 204-210. Retrieved from https://www.sciencedirect.com/science/article/pii/S0889159113004595

Zhongbo Liu, Xuesen Li, Anne R. Simoneau, Mahtab Jafari, Xiaolin Zi (2011). Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Molecular Carcinogenesis 51(3) 257-267. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.20780

Shuang Guan, Jiakang He, Weixiao Guo, Jingyuan Wei, Jing Ju, Xuming Deng (2011). Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses of ovalbumin in mice. Immunopharmacology and Immunotoxicology 33(4) 738-743. Retrieved from https://www.tandfonline.com/doi/abs/10.3109/08923973.2011.567988

Ravichandran Senthilkumar, Rahul Chandran, Thangaraj Parimelazhagan (2014). Hepatoprotective effect of Rhodiola imbricata rhizome against paracetamol-induced liver toxicity in rats. Saudi Journal of Biological Sciences 21(5) 409-416. Retrieved from https://www.sciencedirect.com/science/article/pii/S1319562X14000357

Dora Rita Palumbo, Francesco Occhiuto, Federica Spadaro, Clara Circosta (2011). Rhodiola rosea Extract Protects Human Cortical Neurons against Glutamate and Hydrogen Peroxide-Induced Cell Death Through Reduction in the Accumulation of Intracellular Calcium. Phytotherapy Research 26(6) 878-883. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3662

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Jun J. Mao, Sharon X. Xie, Jarcy Zee, Irene Soeller, Qing S. Li, Kenneth Rockwell, Jay D. Amsterdam (2015). Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine 22(3) 394-399. Retrieved from https://www.sciencedirect.com/science/article/pii/S0944711315000331

Ramona Jurcau, Ioana Jurcau, Cristian Bodescu (2012). Anxiety and salivary cortisol modulation in exercise induced stress, using a phytotherapic product containing Rhodiola Rosea. Palestrica of the Third Millennium Civilization & Sport 13(3) 213-217. Retrieved from https://web.a.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=15821943&AN=80194318&h=kmIgfgP0HVQulmuK2Y69%2baZ41AZRhWDKiW99gImM7XoVaZgKYdA85N8PfkdGsX2OKfZw0CtM%2fDMkZjY2HM5AHw%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d15821943%26AN%3d80194318

Caixia Zhu, Fachun Guan, Chao Wang, Li Hua Jin (2014). The Protective Effects of Rhodiola crenulata Extract on Drosophila melanogaster Gut Immunity Induced by Bacteria and SDS Toxicity. Phytotherapy Research 28(12) 1861-1866. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5215

We Only Cultivate & Harvest The Purest Sourced Botanicals

How and When To Use Gynostemma PLUS

  • Add 1/2 tsp to hot water, coffee, tea, or smoothie.
  • Gynostemma can be taken day or night – with or without food, so enjoy!
  • We recommend once daily, but most importantly listen to your body (if it requires more, less or none:)

What Customers Are Saying:

Average Score: 5 (5 ratings)
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78 years old, more power now............!

I have no problem taken this product. It has given me the ability to do more garden work. Also helps me to be in the day, not all ways 30 to 40 years in the past. When I wake up that’s it, this is my day……………….!!!!

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Awesome!!

This is an amazing product. I Highly recommend primal herbs. I have been taking gynostemma for a few years and it has helped with long term energy, weight management, better sleep, focus etc. I do wish they would continue making the pure gynostemma extract.

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Great product!

I purchased this product two months ago. So far it’s been working great! More mental clarity and more energy. I see some people say it does not taste good!!! Come on guys! what do you expect a botanical extract with medicinal properties taste? taste like chocolate? It tastes however it naturally tastes based on its molecular profile.. Not tasting good is a very little price you have to pay for a greater health benefit.. Indeed if you ever buy a botanical extract that tastes so good, throw it away because it’s most likely fraudulent.

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I take first thing in the morning ever other day seems very poten, pleasant taste

I have not tried this product before, It seems to work well for me. I only started one week ago. So far so good

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Gynostemma

Good product

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